Individualizing Care in Type 2 Diabetes Mellitus
نویسنده
چکیده
variation in the response to metformin has been observed in individuals with genetic variations in the genes coding for MATE1 (SLC47A1) and MATE2 (SLC47A2), which are involved in the extrusion of metformin through the urine. Whereas a greater response to metformin, with reduced levels of HbA1c, was found in association with the rs2252281 variant in the SLC47A1 gene, a reduced response to metformin was observed in patients carriers of the SLC47A2 rs12943590 polymorphism [8]. Globally, these observations indicate that genetic variants of the OCTs are important in the therapeutic efficacy of metformin, being able to contribute to the interindividual variation in metformin response. Thus, genotyping of OCT genes is useful to predict the therapeutic efficacy of metformin.
منابع مشابه
Management of type-2 diabetes mellitus in adults: focus on individualizing non-insulin therapies.
Successful management of hyperglycemia may involve glucose and non-glucose therapies, non-drug approaches, and non-insulin agents. Treatment should be tailored to each patient, with an emphasis on safety.
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